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MDMA Preloading/Postloading Regimin
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bodhi Offline
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MDMA Preloading/Postloading Regimin
This text is copied from http://www.ishkur.com/articles/preloading.php

This article is a MUST READ for anyone who is interested in taking ecstasy. I have rolled a few times without pre or post loading, and it SUCKS. Jaw clenching, jitters, tweaking, etc. The magnesium literally stops ALL jaw clenching!



The Effects of Ecstasy
Think of your brain as the engine of a car. Ecstacy makes you floor the gas pedal and make the car go faster than normal. This is fun. But in driving faster, you use up gas faster as well. When the drug wears off, you obviously have less gas. With less gas, you can't drive as fast as you normally do. Therefore you operate less efficiently. This is what Ecstacy does--it uses up all the gas (called serotonin) in your brain, which leaves your brain exhausted and unable to carry out other functions that it uses serotonin for. Low levels of serotonin often affect eating patterns, sleeping patterns, short term memory, and induce symptoms of depression.

Preloading
The concept behind preloading is to add gas to the tank that MDMA is going to use up, put the car in economy mode so it uses gas more efficiently, and to prevent damage to the engine if its driven too hard, especially if there's no gas in the tank. The following supplements safeguard against the drug's negative side-effects while increasing the enjoyment of the positive ones. All are perfectly legal, and can be found in just about any health food store.

Protection
The following three elements are the most protective to a preloading regimen:
1] 5-HTP - 200-400mg
5-hydroxytrytophan is the direct precursor of serotonin in the body. It enhances the loved-up, empathic feelings and cleans up the comedown. It counteracts negative side effects like depression by putting more gas in the tank and ensuring that you don't run out, and also reduces the chances of oxidised dopamine radicals, which leads to neurotoxicity, which leads to brain damage.
2] Vitamin C - 1000mg+
Vitamin C is a potent antioxidant. It is believed that MDMA is neurotoxic due to oxidized free radicals. As such Vitamin C counteracts these free radicals and helps to minimize damage incurred. It is also water soluble and so protective you really can't go wrong going high.
3] Magnesium - 500-1000mg
One of Magnesium's major roles in the body is in muscle relaxation. It is the antagonist [opposite] of calcium, which helps to induce muscle contraction. The jaw clenching observed on MDMA can be minimized through magnesium supplementation. Added magnesium can also minimize cramping due to dehydration.

Enhancement
The following elements are optional because they enhance the experience rather than protect you from anything specific:
1] L-Tyrosine - 500-1500mg
Think of dopamine as engine oil. When the car runs out of gas (serotonin), it starts using up engine oil in its place, which is very hard on the engine, and can lead to permanent damage. L-Tyrosine is to dopamine what 5-HTP is to serotonin. It is its precursor. Dopamine provides the rushy, body buzz, speedy effects. Increasing L-tyrosine levels enhances these sensations.
2] DLPA - 500-1500mg
DLPA amongst other functions, helps to prolong the duration of action of pleasure inducing neurochemicals.
3] L-Glutamine - 2-5 grams
L-Glutamine is a precursor to neurotransmitters in the brain. It also imparts a protective effect on the brain but not as heavily as 5-HTP or Vitamin C.

Usage
It is preferable to preload on a relatively empty stomach, 1-1.5 hours prior to rolling. Preferably take the supplements with a sugary juice to help the amino acids cross the blood brain barrier. It should be noted that preloading can upset some people's stomachs or cause diarrhea due to the acidity of the stomach. In which case, some Immodium can counteract the diarrhea and does not interfere with a roll, and Tums or any calcium carbonate based antacid can reduce the acidity of the stomach and counteract the feelings of sickness. Remember to experiment and take these things slowly as the sheer volume of pills ingested can upset the stomach. It may seem expensive to buy all these things but to protect your brain against neurotoxic effects and reduce other negative side effects is well worth it.

Postloading
The concept behind postloading is to to fill up the tank after a long, fast ride. You restore the elements depleted by MDMA, and in doing so, bypass negative side effects and clean up your comedown while restoring normal function. The only elements required in a postloading regimen are the protective ones. The following supplements safeguard against the drug's negative side-effects the best.

Protection
1] 5-HTP - 200-400mg
2] Vitamin C - 1000mg+
3] Magnesium - 500-1000mg

Usage
5-HTP, Vitamin C, Magnesium are used for reasons also explained in the preloading regimen. A multivitamin is beneficial to help replace spent micronutrients. Water is of course beneficial. You will know if you are bypassing the negative side effects of serotonin depletion if you can sleep soundly after rolling, and do not experience significant post-MDMA depression or disturbances in verbal processing, short term memory and eating patterns.

Natural sources of trytophan (the precursor to 5-hydroxtrytophan, two steps away from serotonin) include bananas and turkey meat. Turkey's high level of trytophan is the reason why most people feel sleepy after Thanksgiving/Christmas dinners--the high concentration of trytophan converts to serotonin in the bloodstream. Because of serotonin's relationship to the regulation of sleep, fatigue is induced.

This regimen is merely a guideline that has been found to work for many. It should also be noted that changing the ratios of elements can provide different effects. For instance, excessive 5-HTP can mellow out a roll. Not make it mashy, but reduce the speediness of the pill.

Health
120mg of MDMA (about 1-2 caps) is generally all that is needed to completely deplete all your serotonin. Taking more will not increase the feelings, nor prolong them. Although the above supplements help, the best way to restore your serotonin (fill up the tank) is abstinence. Your brain typically takes about two weeks to recover from Ecstacy. And finally, do not combine E with monoamine oxidase inhibitor drugs. Monoamine oxidase is the enzyme that helps to eventually slow down the effects of MDMA, without it, your body is a speeding car without any breaks--it has no way of controlling itself. And remember to have fun, be safe, and drink lots of water.

"If voting made any difference they wouldn't let us do it." - Mark Twain
12-16-2009 12:18 PM
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lawlsacks Offline
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Post: #2
RE: MDMA Preloading/Postloading Regimin
thank you for this!!!
01-05-2010 09:53 AM
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bodhi Offline
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Post: #3
RE: MDMA Preloading/Postloading Regimin
You are quite welcome, I hope it helps you in your future endeavors. Smile

"If voting made any difference they wouldn't let us do it." - Mark Twain
01-05-2010 09:34 PM
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zxy Offline
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Post: #4
RE: MDMA Preloading/Postloading Regimin
wonderful post; very informative. Excellent share from Ishkur.

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01-07-2010 04:35 AM
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DubM Offline
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Post: #5
RE: MDMA Preloading/Postloading Regimin
Yes preloading and post loading helps substantially
01-10-2010 06:35 PM
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hilllll729 Offline
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Post: #6
RE: MDMA Preloading/Postloading Regimin
this is very informative!....i'm thinking about rolling for a Bassnectar show, anyone know if its true that antidepressant's like zoloft cancel the effects of e?
03-07-2010 12:57 AM
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entranced Offline
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Post: #7
RE: MDMA Preloading/Postloading Regimin
(03-07-2010 12:57 AM)hilllll729 Wrote:  this is very informative!....i'm thinking about rolling for a Bassnectar show, anyone know if its true that antidepressant's like zoloft cancel the effects of e?
dont fuck around with SSRI's and e..much diminished effects for sure. I could corroborate this statement with an eleborate explanation of the pharmacological actions of Zoloft (Sertraline HCL), and MDMA, and why it causes a diminished effect, but the language would be a lot and it'd be lengthy ,also, I am lazy right now and you should trust me Smile oh btw are you going to Bassnectar on 4/20 in Buff?? thats when Im going its going to be CRAZYYYYY
03-07-2010 12:35 PM
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hilllll729 Offline
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Post: #8
RE: MDMA Preloading/Postloading Regimin
ok cool thanks haha and nope i'm seein them in pittsburgh!
03-11-2010 08:38 PM
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gnarshred Offline
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Post: #9
RE: MDMA Preloading/Postloading Regimin
Solid post. It is really scary how many kids take drugs without learning anything about them.

I was lucky to be introduced to drugs by an editor on Erowid. It was very helpful.
09-26-2010 10:23 PM
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Denco Offline
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Post: #10
RE: MDMA Preloading/Postloading Regimin
^ Erowid is the shit, been using it for years.

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09-26-2010 10:45 PM
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